MTHFR – It is a genetic defect that reduces the body’s ability to detox itself by 30-70 percent, depending on the variant inherited. 85% of the population has some variation of the mutation, and most don’t know they have it. Dr Gonino recommends this test because the body is unable to detox itself properly, things like heavy metals, fungus, chemicals and histamines build up causing inflammation. MTHFR is an enzyme involved in the metabolism of folate and homocysteine. It plays a role in maintaining cellular folate levels and is a cofactor needed to convert homocysteine to methionine.